AZF microdeletions and partial deletions of AZFc region on the Y chromosome in Moroccan men
نویسندگان
چکیده
منابع مشابه
AZF microdeletions and partial deletions of AZFc region on the Y chromosome in Moroccan men.
AIM To evaluate for the first time the frequency of Y chromosome microdeletions and the occurrence of the partial deletions of AZFc region in Moroccan men, and to discuss the clinical significance of AZF deletions. METHODS We screened Y chromosome microdeletions and partial deletions of the AZFc region of a consecutive group of infertile men (n = 149) and controls (100 fertile men, 76 normosp...
متن کاملMolecular Study of Partial Deletions of AZFc Region of the Y Chromosome in Infertile Men
Background & Aims: The most significant cause of infertility in men is the genetic deletion in the azoospermia factor (AZF) region that is caused by the process of intra- and inter-chromosomal homologous recombination in amplicons. Homologous recombination could also result in partial deletions in AZF region. The aim of this research was to determine the association between the partial AZFc del...
متن کاملO-1: Evaluation of Ethnic Patterns of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia/Severe Oligospermia Referred to Royan Institute
Background: Microdeletions of the long arm of the chromosome Y are the most common molecular genetic cause of severe infertility in men which affect three regions of AZFa, AZFb and AZFc (Azoospermia factor). These regions contain various genes involved in spermatogenesis. The effect of ethnicity on the patterns of Y chromosome microdeletions has not been extensively studied, particulary in Iran...
متن کاملPartial deletions in the AZFc region of the Y chromosome occur in men with impaired as well as normal spermatogenesis.
BACKGROUND Partial deletions of the AZFc region of the Y chromosome were reported to be a significant risk factor for oligo-/azoospermia. In this study, we assessed the occurrence and frequency of partial AZFc microdeletions in patients with spermatogenic failure and in controls with normal spermatogenesis. METHODS In a retrospective study design, gr/gr, b1/b3 and b2/b3 deletions were analyse...
متن کاملDetection of sperm in men with Y chromosome microdeletions of the AZFa, AZFb and AZFc regions.
BACKGROUND Y chromosome microdeletions are associated with severe male factor infertility. In this study, the success rate of testicular sperm retrieval was determined for men with deletions of AZF regions a, b or c. METHODS AZF deletions were detected by PCR of 30 sequence-tagged sites within Yq emphasizing the AZFa, b and c regions. Semen analysis and diagnostic testis biopsy or testicular ...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2007
ISSN: 1008-682X,1745-7262
DOI: 10.1111/j.1745-7262.2007.00290.x